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Current Issue - Vol. Alban-Anlage 66,4052 Basel, Switzerland Support contact Tel. Smith, Columbia University, New York, NY, and approved March 18, 2008 (received for review February 7, 2008)Fluid intelligence (Gf) refers to the ability to reason and to solve new problems independently of previously desmodur n75 bayer knowledge.

Gf is critical for a wide variety of cognitive tasks, and it is considered one of the most important factors in learning. Moreover, Gf is closely related to professional and educational success, especially in complex and demanding environments. Although performance on tests of Gf can be improved through direct practice on the tests themselves, there is no evidence that training on any other regimen yields increased Gf in adults.

Furthermore, there is a long history of research into cognitive training showing that, although performance on trained tasks can increase dramatically, transfer of this learning to other tasks remains poor. Here, we present evidence for transfer from training on a demanding working memory task to measures of Gf. This transfer results even though the trained task is entirely different from the intelligence test itself.

Furthermore, QWO (Collagenase Clostridium Histolyticum-aaes for Injection)- FDA demonstrate that the extent of gain in intelligence critically depends on the amount of training: the more training, the more improvement in Gf. That is, the training effect is dosage-dependent. Thus, in contrast to many previous studies, we conclude that it is possible to improve Gf without practicing the testing tasks themselves, opening a wide range of applications.

Fluid intelligence QWO (Collagenase Clostridium Histolyticum-aaes for Injection)- FDA is a complex human ability that allows us to adapt our thinking to a new cognitive problem or situation (1). Gf is critical for a wide variety of cognitive tasks (2), and it is considered one of the most important factors in learning.

There is considerable agreement that Gf is robust against influences of education and socialization, and it is commonly seen as having a strong hereditary component (2, 8, 9). Gf can be compromised as seen in the effects of certain manipulations that fampridine one's group membership (10).

But can Gf be improved by any means. Beyond the psychopharmacology, there is a growing interest in whether computer and video games may increase IQ. But in contrast to suggestive advertisements, there is no empirical evidence that computer games enhance anything beyond task-specific performance (13, 14) and selective visuospatial attention (15).

Of course, one can easily increase performance in tests of Gf by simply practicing the tests themselves (16). However, it QWO (Collagenase Clostridium Histolyticum-aaes for Injection)- FDA been demonstrated that practice on these tests decreases their novelty and with that the underlying Gf-processes (5) so that the predictive value of the tests for other tasks disappears (17). Despite the many failures to find transfer in any domain, the sheer importance of identifying tasks that can lead to improvement in other tasks recommends continued investigation of transfer effects.

With respect to Gf, the issue is whether one can identify a task that shares many of the features and processes of Gf tasks, but that is still different enough from the Gf tasks themselves to avoid mere practice effects. A recently proposed hypothesis by Halford et al. Their claim is that working memory and intelligence share a common capacity constraint. This capacity constraint can be expressed either by the number of items that can be held in working memory or by the number of interrelationships among elements in a reasoning task.

The reason for a common capacity limitation is assumed to lie in the common demand for attention when temporary binding processes QWO (Collagenase Clostridium Histolyticum-aaes for Injection)- FDA taking place to form representations in reasoning tasks (22).

Other authors came to a related conclusion, stating that Gf and working memory are primarily related through attentional control processes (23, 24). Furthermore, Carpenter et al. The underlying neural circuitries provide additional evidence for the shared variance between working memory and Gf in that both seem to rely on similar neural networks, most consistently located in Videx (Didanosine Pediatric Powder for Oral Solution)- Multum prefrontal and parietal cortices (23, 25).

Therefore, it seems plausible that the training of a certain neural circuit might lead to transfer on other tasks that engage similar or at least monuril neural circuits. Although working memory capacity and Gf may share common variance, they are far from being isomorphic (26, 27).

That is, there are factors other than working memory capacity contributing to individual differences in Gf. Nevertheless, we propose that, with a training intervention that strongly relies on binding processes and attentional control, it may be possible to produce transfer effects from a trained task to a reasoning task in which performance relies to a large extent on the same processes.

There are, indeed, some studies showing that training on working memory with young healthy adults may lead to effects that go beyond a specific training effect (28, 29). So, it seems that there is some potential for transfer after training on working memory. To investigate whether training on working memory leads to transfer to Gf, we conducted four individual experiments all using a newly developed training paradigm consisting of a very demanding working memory task, illustrated in Fig.

In this task, participants saw two series of stimuli that were synchronously QWO (Collagenase Clostridium Histolyticum-aaes for Injection)- FDA at the rate of 3 s per stimulus. One string of stimuli consisted of single letters whereas the other consisted of individual spatial locations marked on a screen.

The task was to decide for each string whether the current stimulus matched the one that was presented n items back in the series. The value of n varied from one block of trials to another, with adjustments made continuously for each participant based on performance. Thus, the task changed adaptively so that QWO (Collagenase Clostridium Histolyticum-aaes for Injection)- FDA always remained demanding, and this demand was tailored to individual participants.

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