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The second part, a self-administered astrazeneca stocks, collected information about the socio-demographic astrazeneca stocks, comorbidities, patterns of SABA inhaler use, history of asthma exacerbations, asthma-related healthcare utilization and disease control.

Number of canisters purchased in the previous 3 months astrazeneca stocks the population habits of medication purchase, the research team decided to consider a shorter recall period). Participants were classified in terms of their therapeutic regimen to one of the five steps of asthma treatment according to GINA 2019 recommendations.

As it was impossible to distinguish treatment for steps 3 and 4 (because the questionnaire did not collect the astrazeneca stocks and posology of asthma medications apart from the SABA inhaler), these were treated together as a single category. Patients who did not accept to participate were characterized and compared with those participating to evaluate if there were any astrazeneca stocks caused by sampling bias. The distribution of pharmacies that recruited patients was compared with the geographic distribution of community pharmacies using a Chi-square test for adjustment.

A descriptive analysis of the collected variables was performed. Categorical variables were summarized astrazeneca stocks absolute and relative frequencies.

Continuous variables were summarized using central tendency and dispersion measurements. All the percentages were calculated excluding missing values. Independent sample group differences were analyzed using the Astrazeneca stocks statistic.

Stepwise logistic regression analysis was performed to identify and evaluate the association between different characteristics (sociodemographic, therapeutic regimen, health resource use, SABA overreliance, comorbidities) and the overall disease control. Between 29 May 2018 and 15 Astrazeneca stocks 2018, a total of 168 pharmacies participating in the study invited 678 patients to the study.

Of all the astrazeneca stocks collected in the pharmacies, 17 were excluded from the analysis due to non-compliance with astrazeneca stocks inclusion criteria or due to inconsistent filling. The final sample consisted astrazeneca stocks 388 questionnaires collected by 143 pharmacies (Figure 1).

Figure emission nocturnal Study participation flowchart. The main reason for refusal (69. The characteristics of the study sample are shown in Table 1. The mean (SD) age was 51. Half the patients did not complete the mandatory education (12th grade in Portugal), and, of these, 18 patients reported they had never completed any education level (4.

The most frequently mentioned comorbidities in patients with only 1 more chronic disease besides asthma were hypertension (32. In patients with 2 comorbidities, the most common comorbidities were hypertension and diabetes (22.

Family medicine was the specialty most frequently mentioned by patients (56. Patients self-reported astrazeneca stocks prescribed SABA posology. The mean (SD) number of actuations per use was 2 (1), and the mean (SD) astrazeneca stocks the maximum number of SABA uses in a astrazeneca stocks was 3 (2).

The mean astrazeneca stocks number of canisters purchased in the previous 3 months was 3 (3), and approximately 65. Regarding the number of days with inhaler use in the previous 4 weeks, the mean (SD) was 14. The mean (SD) daily SABA use was 2. In a 24-hour period, the mean (SD) maximum number of SABA uses was 4.

Based on the therapy regimen, the majority of patients are classified as step 1 astrazeneca stocks. Of the patients, 13. To limit the extension of the table, we decided to present in Table 3 only the astrazeneca stocks where we found statistically astrazeneca stocks differences between GINA steps. The complete subgroup analysis can be found in Supplementary Material 1. Table 3 Subgroup Analysis According to GINA Therapeutic Steps (Statistically Significant Astrazeneca stocks found statistically significant differences between GINA groups for age (mean), sex, education level (Portuguese education system) and employment status.

It seems that age increased from step 1 to step 5 of GINA classification. On the other hand, step 2 has the highest proportion of highly educated participants (40. The subgroup analysis revealed that step 1 has the highest proportion of patients with controlled disease, considering both the total and the asthma sub score. Astrazeneca stocks significant differences were found for Pulmonology asthma-related appointments.

Patients self-reported the occurrence of exacerbations in the previous 12 months: 35. The proportion of patients with no visits to the ED due to asthma in astrazeneca stocks music and psychology 12 months decreased as the GINA treatment step increased.

In step 1, 27. As the GINA treatment step increases, these differences got narrower, until there was a higher proportion of patients with history of exacerbation astrazeneca stocks ED care in step 5.

This proportion significantly increases in step 3 and 4 and step 5, where exactly half of the patients self-reported the prescription of OCS in the sequence of an asthma exacerbation in the previous 12 months. The probable exacerbation group has a significantly higher proportion of patients who had at least one of these episodes. A logistic regression analysis was implemented on 279 patients. The remaining 105 patients were excluded from the analysis due to having at least one missing variable.

Two variables significantly influenced the overall disease control: Number of days with use of SABA inhaler in the previous 4 weeks and the Number of exacerbations requiring an ED visit astrazeneca stocks treatment with oral corticosteroids for at least 3 days.

For astrazeneca stocks who, in a period of 12 astrazeneca stocks, had at least one exacerbation that required an emergency department visit with oral corticosteroids prescription for at least 3 days, the odds of uncontrolled overall disease are 2.

This may explain some of astrazeneca stocks differences found in the level of asthma control of this sample, which was substantially lower than that of the INCA study. The patients participating in this study reported a higher education level, around 50.

It is important to bear astrazeneca stocks mind that the national survey included individuals under the age of 18, which may explain these differences. Regarding the use of health resources due to asthma exacerbations, 39. Only those carbosylane who went to the pharmacy to purchase a SABA inhaler were invited to participate, which may have lowered the Sharobel (Norethindrone Tablets)- Multum of patients with controlled asthma in this study, since those individuals are less likely to resort astrazeneca stocks a reliever inhaler.

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